Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia.

摘要: We hypothesized that the steady-state concentration of intracellular cytarabine 5'-triphosphate (ara-CTPss) in leukemia cells is proportional to dose rate (ara-C) during continuous infusion. To evaluate this possibility, patients with acute myelogenous relapse were treated two sequential schedules serially increasing ara-C rates over a total 36 hours. Schedule I consisted serial infusions 250, 500, and 750 mg/m2 each 12 Subsequently, entered on schedule II received 1,000, 1,500 serially, Steady-state levels ara-CTP achieved within four hours after beginning infusion and, separate studies single rate, shown be maintained beyond Four showed linear rate-dependent increase-of ara-CTPss at all three rates. The one patient sche...