CELLULAR PHARMACOLOGY AND OPTIMAL THERAPEUTIC CONCENTRATIONS OF 1‐β‐D‐ARABINOFURANOSYLCYTOSINE 5‘‐TRIPHOSPHATE IN LEUKEMIC BLASTS DURING TREATMENT OF REFRACTORY LEUKEMIA WITH HIGH‐DOSE 1‐β‐D‐ARABINOFURANOSYLCYTOSINE
作者： William Plunkett , Stephen Iacoboni , Michael J. Keating
DOI: 10.1111/J.1600-0609.1986.TB01590.X
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摘要: The pharmacology of 1-β-D-arabinofuranosylcytosine 5′-triphosphate (ara-CTP) has been studied in the circulating leukemic blasts patients with refractory leukemia during therapy high doses single-agent ara-C. Cellular ara-CTP was analyzed by high-pressure liquid chromatography. median trough concentrations who responded to intermittent high-dose ara-C (3 g/m2 × 4–12 doses) 196 μM, whereas 75 μM lowest concentration that discriminated between complete remission and treatment failure (p=0.03). steady state a dose continuous infusion protocol (2 3 every 12 hr followed 330–3000 mg/m2 4 d) were clustered 79 206 μM. values failures predominantly outside this range (p<0.005). These results suggest optimal for intracellular may be 200
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