Epidermal growth factor receptor structural alterations in gastric cancer.
作者： Cátia Moutinho , Ana R Mateus , Fernanda Milanezi , Fátima Carneiro , Raquel Seruca
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摘要: Background EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of protein, as well gene amplification were associated with a good clinical response to inhibitors. data concerning structural alterations remains controversial. Given its possible therapeutic relevance, we aimed determine frequency and type series primary carcinomas.
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