Integrating smoking cessation into routine care in hospitals-a randomized controlled trial

摘要: Aims To evaluate the effectiveness of a pharmacist-led multi-component smoking cessation programme (GIVE UP FOR GOOD) compared with usual care in hospitalized smokers. Design Randomized, assessor-blinded, parallel-group trial. Setting Three tertiary public hospitals Australia. Participants A total 600 adult in-patient smokers [mean ± standard deviation (SD), age 51 ± 14 years; 64% male] available for 12 months follow-up. Interventions Multi-component hospital behavioural counselling and/or pharmacotherapy provided during stay, on discharge and 1 month post-discharge, further support involving community health professionals (n = 300). Usual comprised routine by (n = 300). Measurements Two primary end-points were tested using intention-to-treat analysis: carbon monoxide (CO)-validated 1-month sustained abstinence at 6-month follow-up verified 12-month follow-up. Smoking status usage assessed baseline, discharge, 1, 6 months. Findings Sustained rates intervention control groups not significantly different both 6 months [11.6% (34 294) versus 12.6% (37 294); odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.55–1.50] 292) 11.2% (33 OR = 1.04, CI = 0.63–1.73]. Secondary end-points, self-reported continuous months, also agreed end-points. Use was higher group, stay [52.3% (157 300) 42.7% (128 300); P = 0.016] after [59.6% (174 43.5% P < 0.001]. Conclusions A did improve either or care.