A comparison of fibrosis progression in chronic liver diseases

摘要: Abstract Background/Aims : No study has compared the liver fibrosis progression rates among chronic diseases and risk factors in order to better organize screening strategies. Methods A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [ n =2313], human immunodeficiency virus (HIV)–HCV co-infection (HIV–HCV =180]), B (HBV =777]), alcoholic disease (ALD =701]), primary biliary cirrhosis (PBC =406]), genetic hemochromatosis (GH =383]) auto-immune (AIH =57]) delta ( =35). The estimated from birth date exposure, when known, first biopsy. Results There highly significant differences progression, most rapid being HIV–HCV (50% percentile at 52 years age) slowest PBC 81 years). was an acceleration with aging. Fibrosis slower females males for HCV, HBV, GH, PBC. In contrast, ALD, more females. Conclusions Rates differ markedly between predominant causes disease, according age gender. Patients are particularly high progression.