Non-random chromosome positioning in human sperm and sex chromosome anomalies following intracytoplasmic sperm injection

摘要: Chromosome paint for chromosome 18 hy b ridised in more than 80% (190/234) of sperm examined, and X just over 40% ( 2 3 0 / 5 ) . The tail was used as a reference to identify apical or basal position. found near the s p e rm almost 60% (113/190), while less 8 This shows that is preferentially l o c ated region nucleus, located regi n placement chromosomes within nucleus m ay have implications assisted reproductive technologi A RT , may help explain apparent increase sexchromosome aberr ations ICSI offspri g could be due fact nuclei localises .I such u i S-phase cell cycle delayed decreased rate nuclear decondensation head, h d ring progression onset firs t mitosis zygote. lead mitotic err rs ri bution during first cleava implying positioning sex sex-chromosome anomalies follow I C S All animal procedures were approved by ORPRC Institutional Care Use Committee. Human obtained from Fo L r at ries after Review Board approva .This research wa sponsored grants GS NIH.