Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women.

摘要: Importance APOL1genotypes are associated with kidney diseases in African American individuals and may influence cardiovascular disease mortality risk, but findings have been inconsistent. Objective To discern whether high-riskAPOL1genotypes stroke postmenopausal women, who at high risk for these outcomes. Design, Setting, Participants The Women's Health Initiative is a prospective cohort that enrolled 161 838 women into clinical trials an observational study between 1993 1998. This includes 11 137 participants had event from enrollment to June 2014. Data analyses were completed January 2017 August 2017. Exposures variants ofAPOL1were genotyped or imputed whole-exome sequencing. Main Outcomes Measures Incident coronary heart disease, failure subtypes, overall cause-specific adjudicated hospital records death certificates. Estimated incidence rates determined each outcome hazard ratios (HR) 95% CIs the associations ofAPOL1groups Results mean (SD) age of was 61.7 (7.1) years. Carriers high-riskAPOL1variants (n = 1370; 12.3%) higher prevalence hypertension, use cholesterol-lowering medications, reduced estimated glomerular filtration rate (eGFR). After 11.0 (3.6) years, carriers hospitalized preserved ejection fraction (HFpEF) than low-risk did showed no differences other In adjusted models, there significant 58% increased HFpEF (HR, 1.58 [95% CI, 1.03-2.41]) among compared low-riskAPOL1variants. association attenuated (HR = 1.50 0.98-2.30]) longer when adjusting baseline eGFR. Conclusions Relevance Status as carrier high-riskAPOL1genotype hospitalization which partly accounted by function. These do not support stroke, women.