Association between shortened leukocyte telomere length and cardio-metabolic outcomes
作者： Steven C. Hunt , Jeremy D. Kark , Abraham Aviv
DOI: 10.1161/CIRCGENETICS.114.000964
关键词:
摘要: > The greatest obstacle to discovery is not ignorance—it the illusion of knowledge . > > D. J. Boorstin In their meta-analysis 27 published studies, D’Mello et al1 show that shortened leukocyte telomere length (LTL) associated with 3 primary end points: myocardial infarction, stroke, and type 2 diabetes mellitus. its findings raise several fundamental issues are worth considering. After discussing major limitations, we focus on central themes: reliability LTL measurements, biological meaning association cardio-metabolic outcomes, future directions research respect cardiovascular disease (CVD) longevity in humans. Article see p 82 The underlying reason for usually lack consensus across studies. This clearly applies field epidemiology, which awash conflicting only context CVD but also cancer longevity. al shows a significant each points, test heterogeneity studies was disease. authors suggest ethnicity or perhaps demography, often ethnicity, might explain some disagreements populations (and studies). Notably, however, 26 analyzed points had odds ratios >1, indicating observed resulted from varying magnitudes positive showing inverse associations. observation lends further support conclusions by associations short diseases. generally consistent those recent systematic review Haycock al2 included 24 many overlapping …
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