Poly(L-lactic acid) nanocomposites with layered double hydroxides functionalized with ibuprofen
作者： Koffi L. Dagnon , Sriram Ambadapadi , Ali Shaito , Sunny M. Ogbomo , Vallerie DeLeon
DOI: 10.1002/APP.30159
关键词:
摘要: The detrimental effect of cell adhesion on polymer surfaces has been a limiting factor in the medical deployment many implants. We examined potential to decrease proliferation while simultaneously increasing mechanical performance through Zn–Al layered double hydroxide (LDH) organically modified with ibuprofen dispersed poly(L-lactic acid) (PLLA). These composites are commonly referred as nanocomposites. thermophysical and properties hybrids were studied wide-angle X-ray diffraction (WAXD), transmission electron microscopy (TEM), differential scanning calorimetry, thermogravimetric analysis, dynamic tensile testing. WAXD TEM results indicated that intercalated exfoliated nanocomposites obtained. storage modulus, ultimate strength improved. LDH affected cold crystallization reduced thermal stability neat PLLA. Smooth muscle cells used for vitro studies It was found proliferation, amount reduction related release. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci,
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