Benzylidene-1,3-dihydro-indol-2-one derivatives as receptor tyrosine kinase inhibitors, particularly of raf kinases

摘要: Compounds of general formula (I) wherein: R 1 is H or optionally joined with 2 to form a fused ring selected from the group consisting five ten membered aryl, heteroaryl heterocyclyl rings, and 3 are independently H, HET, C 1-12 aliphatic, CN, NO , halogen, 10 —OR —SR —S(O)R —SO —NR 11 12 COR CO CONR —NO SO C(NR )NHR —COR —CO —CONR NR —OCONR )NR 6 7 where as defined below; 8 OH, NHSO NHCOCF ; their use in therapy, especially treatment disorders mediated by cRaf1 kinase.