The use of c-raf inhibitors for the treatment of neurodegenerative diseases

作者: Paul C. Chin , Santosh R. D'mello

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摘要: C-Raf inhibitors, especially oxindole derivatives such as 5-lodo-3-[(3,5­dibromo-4-hydroxyphenyl) methylene]-2-indolinone, are used for the prevention or inhibition of neuronal cell death in a mammal suffering from susceptible to neurodegenerative disease, cerebral ischaemia, traumatic injury, epilepsy-associated loss, paralysis, spinal cord injury. inhibitors included manufacture compositions treatment

参考文章(6)
Antoinette GlaxoSmithKline Naylor, David Matthew Glaxosmithkline Wilson, Andrew Kenneth Glaxosmithkline Takle, David Kenneth Glaxosmithkline Dean, Mark James GlaxoSmithKline Bamford, Pyridine derivatives as raf kinase inhibitors ,(2002)
David Matthew Glaxosmithkline Wilson, Andrew Kenneth Glaxosmithkline Takle, David Kenneth Glaxosmithkline Dean, Imidazole derivatives as raf kinase inhibitors ,(2001)
James Marvin Veal, Robert Neil Hunter, Robert Walton Mcnutt, Philip Anthony Harris, Michael Robert Peel, Scott Dickerson, David Kendall Jung, Karen Elizabeth Lackey, Benzylidene-1,3-dihydro-indol-2-one derivatives as receptor tyrosine kinase inhibitors, particularly of raf kinases ,(1998)
Philip John Hedge, Francis Thomas Boyle, Raf kinase inhibitors ,(1997)