Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications.
作者： Hao Zhang , Jie Zhang , James B. Streisand
DOI: 10.2165/00003088-200241090-00003
关键词:
摘要: Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods. Because the oral mucosa is highly vascularised, drugs that are absorbed through the oral mucosa directly enter the systemic circulation, bypassing the gastrointestinal tract and first-pass metabolism in the liver. For some drugs, this results in rapid onset of action via a more comfortable and convenient delivery route than the intravenous route. Not all drugs, however, can be …
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