Gametocytogenesis induction by ammonium compounds in cultured Plasmodium falciparum.

摘要: Abstract Asexual parasites of a strain that seldom or never produce gametocytes in vitro culture began gametocytogenesis after 24 h treatment with RPMI 1640 medium containing concanavalin A (final concentration, 10 μg ml−1) and ammonium carbonate 15 m bicarbonate ml−1). Gametocytogenesis was consistently observed from the 3rd day treatment. Concanavalin enhanced induction by bicarbonate, although does not itself have activity. Whereas no addition acetate 5–25 chloride 5–15 −1). Addition compounds resulted decrease parasitemia, regardless gametocytogenesis.