Bone Turnover and Metabolism in Patients with Early Multiple Sclerosis and Prevalent Bone Mass Deficit: A Population-Based Case-Control Study

摘要: Background: Low bone mass is prevalent in ambulatory multiple sclerosis (MS) patients even shortly after clinical onset. The mechanism not known, but could involve shared etiological risk factors between MS and low such as hypovitaminosis D operating before disease onset, or increased loss aim of this study was to explore the early-stage patients. Methodology/Principal Findings: We performed a population-based case-control comparing turnover (crosslinked N-terminal telopeptide type 1 collagen; NTX, alkaline phosphatase; bALP), metabolism (25-hydroxy- 1, 25-dihydroxyvitamin D, calcium, phosphate, parathyroid hormone), relevant lifestyle 99 newly diagnosed with clinically isolated syndrome (CIS) MS, 159 age, sex, ethnicity matched controls. After adjustment for possible confounders, there were no significant differences NTX (mean 3.3; 95% CI 26.9, 13.5; p=0.519), bALP 1.6; 20.2, 3.5; p=0.081), any parameters related compared markers significantly correlated density, associated presence osteoporosis osteopenia within patient control groups. Intake vitamin reported UV exposure, physical activity did differ significantly. Conclusions/Significance: Bone CIS These findings indicate that deficit caused by recent acceleration loss, are compatible mass.