Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
作者： Peter Rosenberger , Jan M Schwab , Valbona Mirakaj , Eva Masekowsky , Alice Mager
DOI: 10.1038/NI.1683
关键词:
摘要: The neuronal guidance molecule netrin-1 is linked to the coordination of inflammatory responses. Given that mucosal surfaces are particularly prone hypoxia-elicited inflammation, we sought determine function in hypoxia-induced inflammation. We detected hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent induction expression gene encoding (Ntn1) hypoxic epithelia. Neutrophil transepithelial migration studies showed by engaging A2B adenosine receptor (A2BAR) on neutrophils, attenuated neutrophil transmigration. Exogenous suppressed inflammation wild-type but not A2BAR-deficient mice, and hypoxia was enhanced Ntn1(+/-) mice relative Ntn1(+/+) mice. Our demonstrate HIF-1alpha-dependent attenuates at surfaces.
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sci-hub.se 参考文章(52)
Karhausen J, Colgan Sp, Ibla Jc, Implications of hypoxia on mucosal barrier function. Cellular and Molecular Biology. ,vol. 49, pp. 77- 87 ,(2003)
Catherine Ledent, Jean-Marie Vaugeois, Serge N. Schiffmann, Thierry Pedrazzini, Malika El Yacoubi, Jean-Jacques Vanderhaeghen, Jean Costentin, John K. Heath, Gilbert Vassart, Marc Parmentier, Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor Nature. ,vol. 388, pp. 674- 678 ,(1997) , 10.1038/41771
Véronique Corset, Kim Tuyen Nguyen-Ba-Charvet, Christelle Forcet, Emmanuel Moyse, Alain Chédotal, Patrick Mehlen, Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Nature. ,vol. 407, pp. 747- 750 ,(2000) , 10.1038/35037600
Katsumi Komatsuzaki, Sussie Dalvin, T Bernard Kinane, Modulation of Giα2 signaling by the axonal guidance molecule UNC5H2 Biochemical and Biophysical Research Communications. ,vol. 297, pp. 898- 905 ,(2002) , 10.1016/S0006-291X(02)02277-5
Olaf Guckelberger, Xiao Sun, Jean Sévigny, Masato Imai, Elzbieta Kaczmarek, Keiichi Enjyoji, Jonathan Kruskal, Simon Robson, Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thrombosis and Haemostasis. ,vol. 91, pp. 576- 586 ,(2004) , 10.1160/TH03-06-0373
Almut Grenz, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig, The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia PLoS Medicine. ,vol. 5, pp. e137- ,(2008) , 10.1371/JOURNAL.PMED.0050137
Melanie L. Hart, Martina Henn, David Köhler, Doris Kloor, Michel Mittelbronn, Iris C. Gorzolla, Gregory L. Stahl, Holger K. Eltzschig, Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury The FASEB Journal. ,vol. 22, pp. 2784- 2797 ,(2008) , 10.1096/FJ.07-103911
Glenn T. Furuta, Jörn Karhausen, Sean P. Colgan, Randall S. Johnson, John E. Tomaszewski, Volker H. Haase, Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis Journal of Clinical Investigation. ,vol. 114, pp. 1098- 1106 ,(2004) , 10.1172/JCI21086
N. P. Ly, K. Komatsuzaki, I. P. Fraser, A. A. Tseng, P. Prodhan, K. J. Moore, T. B. Kinane, Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 14729- 14734 ,(2005) , 10.1073/PNAS.0506233102
Alex C. Chin, Charles A. Parkos, Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury. Annual Review of Pathology-mechanisms of Disease. ,vol. 2, pp. 111- 143 ,(2007) , 10.1146/ANNUREV.PATHOL.2.010506.091944