Improving the reliability and ecological validity of pharmaceutical risk assessment: Turquoise killifish (Nothobranchius furzeri) as a model in behavioral ecotoxicology.

摘要: Pharmaceuticals are essential for human well-being, but their increasing and continuous use pollutes the environment. Although behavioral ecotoxicology is increasingly advocated to assess effects of pharmaceutical pollution on wildlife ecosystems, a consensus actual environmental risks lacking most compounds. The main limitation lack standardized reproducible tests that based sensitive endpoints accommodate high ecological relevance. In present study, we assessed impact 3-wk exposure antidepressant fluoxetine multiple traits in promising new model organism Nothobranchius furzeri (turquoise killifish). Overall, our study shows can feeding behavior, habitat choice novel environment, antipredator response N. individuals; spontaneous activity exploration tendency were less pronounced. However, became only apparent when individuals exposed concentrations 10 times higher than typical natural aquatic environments. Ecotoxicologists challenged maximize both reliability validity risk assessments pollutants. Our contributes development time- cost-efficient, ecotoxicological test sensitive, ecologically relevant furzeri. Environ Toxicol Chem 2019;38:262-270. © 2018 SETAC.