Protective efficacy of an H5N1 DNA vaccine against challenge with a lethal H5N1 virus in quail.
作者： Junping Li , Yongping Jiang , Shuangcheng Zhao , Xiaofei Chang , Jinxiong Liu
DOI: 10.1637/10150-040812-RESNOTE.1
关键词:
摘要: SUMMARY. Some H5N1 avian influenza viruses (AIVs) are lethal to quail; however, the use of inactivated vaccines in these birds is largely restricted because side effects caused by oil adjuvants. Here we evaluated protective efficacy a DNA vaccine against challenge with highly pathogenic virus (HPAIV) quail. Groups ten 3-wk-old quail were intramuscularly inoculated three times at 3-wk intervals 10, 15, 30, or 60 µg, respectively, plasmid pCAGGoptiHA, which expresses codon-optimized hemagglutinin gene A/goose/Guangdong/1/96 (GS/GD/96). The control group was phosphate-buffered saline. Hemagglutination-inhibition (HI) antibodies monitored every week after primary vaccination. challenged intranasally 105 EID50 heterologous HPAIV A/duck/Fujian/31/2007 (DK/FJ/31) (H5N1) 2 wk third inoculation. Oropharyngeal and cloacal swab specimens collected 3, 5, 7 days inoculation, ...
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aaapjournals.info参考文章(21)
D E Swayne, Vaccines for List A poultry diseases: emphasis on avian influenza. Developments in biologicals. ,vol. 114, pp. 201- 212 ,(2003)
N. Y. Kung, Y. Guan, N. R. Perkins, L. Bissett, T. Ellis, L. Sims, R. S. Morris, K. F. Shortridge, J. S M. Peiris, The Impact of a Monthly Rest Day on Avian Influenza Virus Isolation Rates in Retail Live Poultry Markets in Hong Kong Avian Diseases. ,vol. 47, pp. 1037- 1041 ,(2003) , 10.1637/0005-2086-47.S3.1037
Thierry van den Berg, Bénédicte Lambrecht, Sylvie Marché, Mieke Steensels, Steven Van Borm, Michel Bublot, Influenza vaccines and vaccination strategies in birds. Comparative Immunology Microbiology and Infectious Diseases. ,vol. 31, pp. 121- 165 ,(2008) , 10.1016/J.CIMID.2007.07.004
Yongping Jiang, Kangzhen Yu, Hongbo Zhang, Pingjing Zhang, Chenjun Li, Guobin Tian, Yanbing Li, Xijun Wang, Jinying Ge, Zhigao Bu, Hualan Chen, Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antiviral Research. ,vol. 75, pp. 234- 241 ,(2007) , 10.1016/J.ANTIVIRAL.2007.03.009
R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro, H. L. Robinson, E. F. Fynan, DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 11478- 11482 ,(1993) , 10.1073/PNAS.90.24.11478
Elham F. El-Zoghby, Abdel-Satar Arafa, Mohamed K. Hassan, Mona M. Aly, Abdullah Selim, Walid H. Kilany, Usama Selim, Soad Nasef, Mohamed G. Aggor, E. M. Abdelwhab, Hafez M. Hafez, Isolation of H9N2 avian influenza virus from bobwhite quail (Colinus virginianus) in Egypt Archives of Virology. ,vol. 157, pp. 1167- 1172 ,(2012) , 10.1007/S00705-012-1269-Z
H.L. Robinson, L.A. Hunt, R.G. Webster, Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA Vaccine. ,vol. 11, pp. 957- 960 ,(1993) , 10.1016/0264-410X(93)90385-B
David L. Suarez, Stacey Schultz-Cherry, The Effect of Eukaryotic Expression Vectors and Adjuvants on DNA Vaccines in Chickens Using an Avian Influenza Model Avian Diseases. ,vol. 44, pp. 861- 868 ,(2000) , 10.2307/1593058
HuaLan Chen, H5N1 avian influenza in China Science in China Series C: Life Sciences. ,vol. 52, pp. 419- 427 ,(2009) , 10.1007/S11427-009-0068-6
JSM Peiris, WC Yu, CW Leung, CY Cheung, WF Ng, JM Nicholls, TK Ng, KH Chan, ST Lai, WL Lim, KY Yuen, Y Guan, None, Re-emergence of fatal human influenza A subtype H5N1 disease The Lancet. ,vol. 363, pp. 617- 619 ,(2004) , 10.1016/S0140-6736(04)15595-5