Determining the effects of inositol supplementation and the opi1 mutation on ethanol tolerance of Saccharomyces cerevisiae
作者： Erin L. Krause , Manuel J. Villa-García , Susan A. Henry , Larry P. Walker
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摘要: Abstract The yeast Saccharomyces cerevisiae is an important microorganism for the ethanol fuel industry. As with many microorganisms, production and accumulation of certain metabolites, such as ethanol, can have a detrimental effect on cell growth productivity. Yeast cells containing higher concentration phosphatidylinositol (PI) in cellular membrane, due to inositol supplementation media, been shown tolerate produce concentrations ethanol. specific goal our research was assess effects media well compare tolerance wild-type S. mutant, opi1 strain (opi=overproduction inositol). OPI1 gene product negative regulatory factor that controls transcription INO1 structural gene, which encodes enzyme catalyzing limiting step biosynthesis inositol, is, conversion glucose-6-phosphate inositol-3-phosphate. Up...
sci-hub.se 参考文章(24)
Lonnie O'Neal Ingram, Thomas M. Buttke, Effects of Alcohols on Micro-Organisms Advances in Microbial Physiology Volume 25. ,vol. 25, pp. 253- 300 ,(1985) , 10.1016/S0065-2911(08)60294-5
S A Henry, J P Hirsch, M J White, The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper. Journal of Biological Chemistry. ,vol. 266, pp. 863- 872 ,(1991) , 10.1016/S0021-9258(17)35253-5
Michael J. White, John M. Lopes, Susan A. Henry, Inositol metabolism in yeasts. Advances in Microbial Physiology. ,vol. 32, pp. 1- 51 ,(1991) , 10.1016/S0065-2911(08)60004-1
S Kajiwara, A Shirai, T Fujii, T Toguri, K Nakamura, K Ohtaguchi, Polyunsaturated fatty acid biosynthesis in Saccharomyces cerevisiae: expression of ethanol tolerance and the FAD2 gene from Arabidopsis thaliana. Applied and Environmental Microbiology. ,vol. 62, pp. 4309- 4313 ,(1996) , 10.1128/AEM.62.12.4309-4313.1996
D. Susan Thomas, A. H. Rose, Inhibitory effect of ethanol on growth and solute accumulation by Saccharomyces cerevisiae as affected by plasma-membrane lipid composition. Archives of Microbiology. ,vol. 122, pp. 49- 55 ,(1979) , 10.1007/BF00408045
Tony D'amore, Chandra J. Panchal, Inge Russell, G. G. Stewart, A study of ethanol tolerance in yeast. Critical Reviews in Biotechnology. ,vol. 9, pp. 287- 304 ,(1989) , 10.3109/07388558909036740
Gregory P. Casey, W.M. Mike Ingledew, Ethanol Tolerance in Yeasts Critical Reviews in Microbiology. ,vol. 13, pp. 219- 280 ,(1986) , 10.3109/10408418609108739
Z Chi, S D Kohlwein, F Paltauf, Role of phosphatidylinositol (PI) in ethanol production and ethanol tolerance by a high ethanol producing yeast Journal of Industrial Microbiology & Biotechnology. ,vol. 22, pp. 58- 63 ,(1999) , 10.1038/SJ.JIM.2900603
Rodney P. Jones, Paul F. Greenfield, Ethanol and the fluidity of the yeast plasma membrane Yeast. ,vol. 3, pp. 223- 232 ,(1987) , 10.1002/YEA.320030403
C. P. Cartwright, F. J. Verzey, A. H. Rose, Effect of ethanol on activity of the plasma-membrane ATPase in, and accumulation of glycine by, Saccharomyces cerevisiae. Microbiology. ,vol. 133, pp. 857- 865 ,(1987) , 10.1099/00221287-133-4-857