Clinical utility of high-resolution pulmonary computed tomography in children with antibody deficiency disorders

摘要: Objective. To assess the value of high-resolution computed tomography (HRCT) in determining extent and significance lung disease children with antibody deficiency states. Materials methods. Seventy HRCT scans performed on 37 various disorders over a 5-year period were retrospectively scored using previously described demerit scoring system (0–25 0 = worst, 25 best). Points are subtracted from increasing severity disease. The potential correlations between CT scores clinical factors, including age at diagnosis, CT, type immunoglobulin deficiency, length respiratory symptoms before number pneumonias type, success therapy, patient compliance pulmonary function tests (PFTs), assessed. Results. Of children, demonstrated 22 abnormal (CT score ≤ 22). All nine bronchiectasis lower lobe right middle predominance. Statistically significant seen score) diagnosis (p 0.01), therapy (P 0.001) PFTs 0.0008). seven who followed repeated scans, 4 7 which improved high-dose intravenous replacement therapy. Conclusion. is useful adjunct to demonstrate during Correlation factors suggests higher risk group needing more aggressive management.