Somatic mutations of the ERBB4 kinase domain in human cancers.

摘要: The EGFR family consists of 4 receptor tyrosine kinases, (ERBB1), ERBB2 (HER2), ERBB3 (HER3) and ERBB4 (HER4). Recent reports revealed that the kinase domains both (ERBB1) gene were somatically mutated in human cancers, raising possibility other ERBB members possess somatic mutations cancers. Here, we performed mutational analysis domain by polymerase chain reaction-single-strand conformation polymorphism assay 595 cancer tissues from stomach, lung, colon breast. We detected 3 180 gastric carcinomas (1.7%), 104 colorectal (2.9%), 5 217 nonsmall cell lung cancers (2.3%) 1 94 breast (1.1%). 12 consisted in-frame duplication mutation 8 missense exons, introns. simultaneously analyzed EGFR, ERBB2, K-RAS, PIK3CA BRAF genes samples with found carcinoma also harbored K-RAS mutation. Our study demonstrated addition to occurs common suggested alterations ERBB4-mediated signaling pathway may contribute development