Epidermal growth factor receptor: mechanisms of activation and signalling.

作者: Robert N Jorissen , Francesca Walker , Normand Pouliot , Thomas PJ Garrett , Colin W Ward

DOI: 10.1016/S0014-4827(02)00098-8

关键词: Heparin-binding EGF-like growth factorEpidermal growth factorGrowth factor receptor inhibitorERBB3Insulin-like growth factor 1 receptorCell biologyGrowth factor receptorBiologyA431 cellsEpidermal growth factor receptor

摘要: … and function of the epidermal growth factor (EGF) … The epidermal growth factor receptor (EGFR) regulates the intracellular effects of ligands such as EGF and transforming growth factor-…

参考文章(293)
Takanori Moriki, Hiroko Maruyama, Ichi N Maruyama, Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain11Edited by B. Holland Journal of Molecular Biology. ,vol. 311, pp. 1011- 1026 ,(2001) , 10.1006/JMBI.2001.4923
Laurie G. Hudson, Lisa J. McCawley, Contributions of the epidermal growth factor receptor to keratinocyte motility. Microscopy Research and Technique. ,vol. 43, pp. 444- 455 ,(1998) , 10.1002/(SICI)1097-0029(19981201)43:5<444::AID-JEMT10>3.0.CO;2-C
Herman Meisner, Michael P. Czech, Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor Journal of Biological Chemistry. ,vol. 270, pp. 25332- 25335 ,(1995) , 10.1074/JBC.270.43.25332
Xiang-Xi Xu, Taolin Yi, Bo Tang, J David Lambeth, Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene. ,vol. 16, pp. 1561- 1569 ,(1998) , 10.1038/SJ.ONC.1201678
Elsa G. Barbacci, Bradley C. Guarino, Justin G. Stroh, David H. Singleton, Kenneth J. Rosnack, James D. Moyer, Glenn C. Andrews, The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding Journal of Biological Chemistry. ,vol. 270, pp. 9585- 9589 ,(1995) , 10.1074/JBC.270.16.9585
Morgan Huse, John Kuriyan, The Conformational Plasticity of Protein Kinases Cell. ,vol. 109, pp. 275- 282 ,(2002) , 10.1016/S0092-8674(02)00741-9
Sean P. Palecek, Joseph C. Loftus, Mark H. Ginsberg, Douglas A. Lauffenburger, Alan F. Horwitz, Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness Nature. ,vol. 385, pp. 537- 540 ,(1997) , 10.1038/385537A0
A. Ullrich, L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L. V. Mayes, N. Whittle, M. D. Waterfield, P. H. Seeburg, Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells Nature. ,vol. 309, pp. 418- 425 ,(1984) , 10.1038/309418A0
Ari Hashimoto, Mari Kurosaki, Noriko Gotoh, Masabumi Shibuya, Tomohiro Kurosaki, Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway Journal of Biological Chemistry. ,vol. 274, pp. 20139- 20143 ,(1999) , 10.1074/JBC.274.29.20139