Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection.

摘要: Enteropathogenic Escherichia coli (EPEC) colibacillosis represents a major cause of lethal diarrhea in young children developing countries. EPEC strains also infect numerous mammal species and represent economical problem rabbit industry. Protection against this pathogen is challenging goal both humans other species. Despite good knowledge the pathogenicity mechanisms EPEC, intrinsic environmental factors that control expression virulence mammals remain unknown. For instance, exacerbated sensitivity to infection still unexplained. Our was investigate if age or factors, like milk consumption, could be determinants trigger disease. We used rabbits as an animal model study role infection. Weaned suckling were orally inoculated with strain E22 (O103:H2:K-) at 28 days age, evolution disease investigated two groups. In addition, order better characterize interactions between we determined vitro bacterial growth abilities cells adhere epithelial presence milk. results demonstrate protective vivo association antibacterial activity. These effects are independent specific anti-EPEC antibodies.