Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells.
作者： Qinwen Wang , Zhengtang Chen , Xinwei Diao , Shengbing Huang
DOI: 10.1016/J.CANLET.2010.12.007
关键词:
摘要: In this study, we demonstrated that YM155, a novel survivin suppressant, induced both apoptosis, and autophagy was shown by conversion of cytosolic-associated protein light chain 3 (LC3I) into autophagosome-associated form (LC3II) punctate fluorescence pattern an ectopic GFP-LC3 protein. The lysosomal inhibitor chloroquine further accumulated YM155-induced LC3II, indicating increase autophagic flux. Ectopic expression significantly attenuated apoptosis autophagy, whereas siRNA autophagy. Furthermore, inhibition either early or late events demonstrating induction proceeds apoptosis. conclusion, suppression YM155 induces autophagy-dependent plays pro-apoptotic role thereby unveiling mechanism in prostate cancer cells.
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