Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice

摘要: The inhibitor of apoptosis proteins (IAPs) are a family antiapoptotic that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates IAPs modulate cell division, cycle progression, signal transduction pathways. As our basic understanding has increased, the knowledge is being translated into clinically useful applications in diagnosis treatment malignancy. For example, such as survivin investigated diagnostic markers for presence occult In addition, IAP overexpression poor prognostic marker variety solid tumors hematologic malignancies. Finally, attractive therapeutic targets, efforts under way to develop antisense chemical inhibitors may be all these potential clinical applications, however, challenge remains incorporate findings actual practice.