Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography® Platelet Mapping™

摘要: Background Increasing numbers of patients prescribed clopidogrel and aspirin are presenting for non-elective surgery. No consensus on the timing surgery exists after withdrawal antiplatelet tests platelet function not routinely available. The Thrombelastography® Platelet Mapping™ (TEG-PM) assay is designed to assess inhibition secondary therapy. We assessed its ability detect in preoperative acute surgical patients. Methods conducted a prospective observational study three groups patients: those taking or up admission, control group. TEG-PM was performed day admission alternate days until Results Mean ( sd ) thromboxane A2 receptor group 17.5% (23.8) (n=20), 52.6% (32.3) (n=18) group, 31.9% (27.6) (n=21) (P adenosine diphosphate (ADP) 47.8% (18.9) (19.7) 71.5% (18.4) Conclusions can identify statistically significant therapy; however, overlap between likely limit clinical usefulness this test.