Race and recurrence in women who undergo neoadjuvant chemotherapy for breast cancer

作者: Marissa Howard-McNatt , Julia Lawrence , Susan A. Melin , Edward A. Levine , Perry Shen

DOI: 10.1016/J.AMJSURG.2013.01.009

关键词:

摘要: BACKGROUND: Black women can have worse outcomes than white with breast cancer. We examined survival in black and who received neoadjuvant chemotherapy. METHODS: identified 98 stage II or III cancer underwent Women inflammatory cancer, T4 disease, metastases were excluded. Data analyzed using the Fisher exact test Kaplan-Meier method. RESULTS: From cohort, 69 included. The median follow-up was 6.2 years. estrogen receptor status similar. White tended to overexpress human epidermal growth factor 2 (HER2) (P 5.091). pretreatment T T3. All similar 5-year progression-free better for compared (78% vs 58%, P 5 .05). overall .095). CONCLUSIONS: characteristics of receiving chemotherapy had a disease-free survival. same.

参考文章(17)
Priya Rastogi, Stewart J Anderson, Harry D Bear, Charles E Geyer, Morton S Kahlenberg, André Robidoux, Richard G Margolese, James L Hoehn, Victor G Vogel, Shaker R Dakhil, Deimante Tamkus, Karen M King, Eduardo R Pajon, Mary Johanna Wright, Jean Robert, Soonmyung Paik, Eleftherios P Mamounas, Norman Wolmark, None, Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27 Journal of Clinical Oncology. ,vol. 26, pp. 778- 785 ,(2008) , 10.1200/JCO.2007.15.0235
Wendy A. Woodward, Eugene H. Huang, Marsha D. McNeese, George H. Perkins, Susan L. Tucker, Eric A. Strom, Lavinia Middleton, Karin Hahn, Gabriel N. Hortobagyi, Thomas A. Buchholz, African-American race is associated with a poorer overall survival rate for breast cancer patients treated with mastectomy and doxorubicin-based chemotherapy Cancer. ,vol. 107, pp. 2662- 2668 ,(2006) , 10.1002/CNCR.22281
Charles M. Perou, Therese Sørlie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffrey, Christian A. Rees, Jonathan R. Pollack, Douglas T. Ross, Hilde Johnsen, Lars A. Akslen, Øystein Fluge, Alexander Pergamenschikov, Cheryl Williams, Shirley X. Zhu, Per E. Lønning, Anne-Lise Børresen-Dale, Patrick O. Brown, David Botstein, Molecular portraits of human breast tumours Nature. ,vol. 406, pp. 747- 752 ,(2000) , 10.1038/35021093
R. M. Elledge, G. M. Clark, G. C. Chamness, C. K. Osborne, Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. Journal of the National Cancer Institute. ,vol. 86, pp. 705- 712 ,(1994) , 10.1093/JNCI/86.9.705
R J Kurman, C Redmond, C P Hunter, V W Chen, P Correa, M Sobhan, J W Eley, X C Wu, D Austin, H Muss, Histological characteristics of breast carcinoma in blacks and whites. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 3, pp. 127- 135 ,(1994)
T. Sorlie, C. M. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M. B. Eisen, M. van de Rijn, S. S. Jeffrey, T. Thorsen, H. Quist, J. C. Matese, P. O. Brown, D. Botstein, P. E. Lonning, A.-L. Borresen-Dale, Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 10869- 10874 ,(2001) , 10.1073/PNAS.191367098
James D Brenton, Lisa A Carey, Ahmed Ashour Ahmed, Carlos Caldas, None, Molecular Classification and Molecular Forecasting of Breast Cancer: Ready for Clinical Application? Journal of Clinical Oncology. ,vol. 23, pp. 7350- 7360 ,(2005) , 10.1200/JCO.2005.03.3845
Lisa A. Newman, Breast Cancer in African-American Women Oncologist. ,vol. 10, pp. 1- 14 ,(2005) , 10.1634/THEONCOLOGIST.10-1-1
Harry D Bear, Stewart Anderson, Roy E Smith, Charles E Geyer Jr, Eleftherios P Mamounas, Bernard Fisher, Ann M Brown, Andre Robidoux, Richard Margolese, Morton S Kahlenberg, Soonmyung Paik, Atilla Soran, D Lawrence Wickerham, Norman Wolmark, None, Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer : National surgical adjuvant breast and bowel project protocol B-27 Journal of Clinical Oncology. ,vol. 24, pp. 2019- 2027 ,(2006) , 10.1200/JCO.2005.04.1665
Lisa A. Carey, Charles M. Perou, Chad A. Livasy, Lynn G. Dressler, David Cowan, Kathleen Conway, Gamze Karaca, Melissa A. Troester, Chiu Kit Tse, Sharon Edmiston, Sandra L. Deming, Joseph Geradts, Maggie C. U. Cheang, Torsten O. Nielsen, Patricia G. Moorman, H. Shelton Earp, Robert C. Millikan, Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study JAMA. ,vol. 295, pp. 2492- 2502 ,(2006) , 10.1001/JAMA.295.21.2492