Experimental trials with Gd(DO3A)—a nonionic magnetic resonance contrast agent
作者： Val M. Runge , Dean M. Kaufman , Michael L. Wood , Lester S. Adelman , Stanley Jacobson
DOI: 10.1016/0883-2897(89)90071-8
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摘要: Abstract Gd(DO3A), a member of new family nonionic MRI contrast agents, was evaluated in vivo rat model. In 10 animals, enhancement an intracerebral glioma studied following Gd(DO3A) injection. Correlation with tissue pathology obtained all cases. Comparative studies renal were performed 15 utilizing disodium-Gd(DTPA) 2− , sodium-Gd(DOTA) − and Gd(DO3A). With the model, administration provided altered blood-brain barrier, thus permitting identification bulk neoplastic lesion. revealed that normal medulla equal or superior
sci-hub.se 参考文章(15)
W. Wechsler, A. Koestner, J. A. Swenberg, Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. American Journal of Pathology. ,vol. 63, pp. 37- 56 ,(1971)
DH Carr, J Brown, GM Bydder, RE Steiner, HJ Weinmann, U Speck, AS Hall, IR Young, Gadolinium-DTPA as a contrast agent in MRI : Initial clinical experience in 20 patients American Journal of Roentgenology. ,vol. 143, pp. 215- 224 ,(1984) , 10.2214/AJR.143.2.215
P. Wedeking, M. Tweedle, Comparison of the biodistribution of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n in mice. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. ,vol. 15, pp. 395- 402 ,(1988) , 10.1016/0883-2897(88)90009-8
R I Pettigrew, L Avruch, W Dannels, J Coumans, M E Bernardino, Fast-field-echo MR imaging with Gd-DTPA: Physiologic evaluation of the kidney and liver Radiology. ,vol. 160, pp. 561- 563 ,(1986) , 10.1148/RADIOLOGY.160.2.3726139
M. F. TWEEDLE, S. M. EATON, W. C. ECKELMAN, G. T. GAUGHAN, J. J. HAGAN, P. W. WEDEKING, F. J. YOST, Comparative chemical structure and pharmacokinetics of MRI contrast agents. Investigative Radiology. ,vol. 23, ,(1988) , 10.1097/00004424-198809001-00049
G. M. Bydder, D. P. E. Kingsley, J. Brown, H. P. Niendorf, I. R. Young, MR Imaging of Meningiomas Including Studies With and Without Gadolinium-DTPA Journal of Computer Assisted Tomography. ,vol. 9, pp. 690- 697 ,(1985) , 10.1097/00004728-198507010-00006
C. F. G. C. Geraldes, A. D. Sherry, R. D. Brown, S. H. Koenig, Magnetic field dependence of solvent proton relaxation rates induced by Gd3+ and Mn2+ complexes of various polyaza macrocyclic ligands: Implications for NMR imaging Magnetic Resonance in Medicine. ,vol. 3, pp. 242- 250 ,(1986) , 10.1002/MRM.1910030207
HJ Weinmann, RC Brasch, WR Press, GE Wesbey, Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. American Journal of Roentgenology. ,vol. 142, pp. 619- 624 ,(1984) , 10.2214/AJR.142.3.619
R Felix, W Schörner, M Laniado, H P Niendorf, C Claussen, W Fiegler, U Speck, Brain tumors: MR imaging with gadolinium-DTPA. Radiology. ,vol. 156, pp. 681- 688 ,(1985) , 10.1148/RADIOLOGY.156.3.4040643
V M Runge, S Jacobson, M L Wood, D Kaufman, L S Adelman, MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA. Radiology. ,vol. 166, pp. 835- 838 ,(1988) , 10.1148/RADIOLOGY.166.3.3401296