Preliminary analysis of the antinociceptive activity of zerumbone.
作者： M.R. Sulaiman , E.K. Perimal , Z.A. Zakaria , F. Mokhtar , M.N. Akhtar
DOI: 10.1016/J.FITOTE.2009.02.002
关键词:
摘要: We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate mice. 1 given by intraperitoneal route produced significant dose-dependent effect all models used. In addition, was reversed non-selective opioid receptor antagonist naloxone, suggesting that system is involved its analgesic mechanism action.
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