Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral Transfer

摘要: Type I interferons (IFN) inhibit several steps of the human immunodeficiency virus type 1 (HIV) replication cycle. Some HIV proteins, like Vif and Vpu, directly counteract IFN-induced restriction factors. Other mechanisms are expected to modulate extent IFN inhibition. Here, we studied impact on various aspects in primary T lymphocytes. We confirm potent effect Gag p24 production supernatants. Interestingly, had a more limited spread, measured as appearance Gag-expressing cells. Primary isolates displayed similar differences inhibition release spread. Virus emergence was consequence suboptimal not due selection resistant variants. Cell-to-cell transfer, means replication, less sensitive than infection by cell-free virions. These results suggest that active cell cultures initially thought. They help explain incomplete protection naturally secreted during unsatisfactory outcome treatment HIV-infected patients.