pl5 INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

作者: Gregory J. Hannon , David Beach

DOI: 10.1038/371257A0

关键词:

摘要: … in these cell lines, any contribution that p27 might make to TGF-ß-mediated cell cycle arrest … effector of TGF-ß-mediated cell cycle arrest through inhibition of CDK4 and CDK6 kinases. …

参考文章(28)
B. Ozanne, J. Feramisco, C. Stiles, Cancer cells. 3: Growth factors and transformation Cold Spring Harbor Laboratory,Cold Spring Harbor, NY. ,(1985)
Parry D, Dickson C, Peters G, Holder A, Bates S, MacAllan D, Bonetta L, CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene. ,vol. 9, pp. 71- 79 ,(1994)
J L Bolognia, T L Yang-Feng, E M Petty, L H Gibson, A E Bale, J W Fountain, D E Housman, Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s). American Journal of Human Genetics. ,vol. 53, pp. 96- 104 ,(1993)
Ulrich Rodeck, Peter C. Nowell, Anna Bossler, Ullrich Graeven, Csaba Kari, Floyd E. Fox, Cornelius Knabbe, Transforming Growth Factor β Production and Responsiveness in Normal Human Melanocytes and Melanoma Cells Cancer Research. ,vol. 54, pp. 575- 581 ,(1994)
Suresh C. Jhanwar, Joseph R. Testa, You Yong Lu, Jin Quan Cheng, Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas Cancer Research. ,vol. 53, pp. 4761- 4763 ,(1993)
T. Masui, L. M. Wakefield, J. F. Lechner, M. A. LaVeck, M. B. Sporn, C. C. Harris, Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 2438- 2442 ,(1986) , 10.1073/PNAS.83.8.2438
M. Josefa Bello, Angel Pestaña, Juan A. Rey, Jose M. De Campos, Jesus Vaquero, M. Elena Kusak, Jose L. Sarasa, Molecular and cytogenetic analysis of chromosome 9 deletions in 75 malignant gliomas Genes, Chromosomes and Cancer. ,vol. 9, pp. 33- 41 ,(1994) , 10.1002/GCC.2870090107
Mark E. Ewen, Hayla K. Sluss, Laura L. Whitehouse, David M. Livingston, TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest Cell. ,vol. 74, pp. 1009- 1020 ,(1993) , 10.1016/0092-8674(93)90723-4
K Polyak, J Y Kato, M J Solomon, C J Sherr, J Massague, J M Roberts, A Koff, p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes & Development. ,vol. 8, pp. 9- 22 ,(1994) , 10.1101/GAD.8.1.9
R. Day, B. Johnson, M. Skolnick, A Kamb, N. Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S. Tavtigian, E Stockert, A cell cycle regulator potentially involved in genesis of many tumor types Science. ,vol. 264, pp. 436- 440 ,(1994) , 10.1126/SCIENCE.8153634