Age differences in corneal hydration control.

摘要: Dynamic changes in corneal thickness were measured eight young and older normal subjects (mean ages 24.4 ± 4.3 years 71.9 7.3 years, respectively) to provide data for quantitative assessment of hydration control thereby information studying age differences this important aspect function. For each subject, pachometry obtained by (A) monitoring recovery following hypoxic stress, either (Bl) measuring after sleep or (B2) the late afternoon. The combined from A Bl B2 analyzed through an exponential model on the: (1) percent per hour (PRPH) induced hydration; (2) open-eye steady-state (OESS) thickness; (3) residual swelling just before stress test; (4) amount edema stress; (5) time reach 95% back OESS level (T95%). results show that between two groups, there are substantial some characteristics while other aspects similar. example, mean PRPH values (58.9 7.8% 34.2 6.4%/hr) significantly higher younger (/> = 0.0002) (207 42 min 452 ±11 7 min) was lower vs. group (P 0.0002). Also, groups observed at midmorning starting 32.1 4.8 urn above thickness, greater than (1.84 7.1 urn) found with However, absolute 64.2 10.6 fim 66.0 9.3 /im subjects, did not differ 0.96), nor levels, 516 34 Mm 537 28.9 0.234). These strong evidence decreases age. test methods used study good promise applicability clinical setting so certain "at risk" patients can be tested monitored ophthalmological office. prove clinically applicable, more work is needed refine procedures make them as convenient efficient possible. Invest Ophthalmol Vis Sci 30:392-399,1989