Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas

摘要: Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has been used to investigate copy number changes in 48 colorectal cancer (CRC) cell lines and 37 primary CRCs. The samples were divided for analysis according the type instability that they exhibit, microsatellite (MSI) or chromosomal (CIN). Consistent identified, including gain chromosomes 20, 13, 8q smaller regions amplification such as chromosome 17q11.2-q12. Loss 18q was recurrent finding along deletion discrete 4q34-q35. overall pattern change strikingly similar between cancers few obvious exceptions loss 6 15 12p former. A greater aberrations detected CIN+ than MSI+ well differences extent reported. For example, 8p common event but often found be gained cancers. In addition, target on appeared differ, 8q24.21 amplified frequently 8q24.3 samples. genes interest are located within aberrated regions, which likely importance development progression CRC.