The effects of calcitriol and nicotinamide on residual pancreatic β‐cell function in patients with recent‐onset Type 1 diabetes (IMDIAB XI)
作者： D. Pitocco , A. Crino , E. Di Stasio , S. Manfrini , C. Guglielmi
DOI: 10.1111/J.1464-5491.2006.01921.X
关键词:
摘要: Background A number of recent studies underline the importance vitamin D in pathogenesis Type 1 diabetes (T1D). Aims The aim this study was to investigate whether supplementation with active form (calcitriol) subjects recent-onset T1D protects residual pancreatic β-cell function and improves glycaemic control (HbA1c insulin requirement). Methods In open-label randomized trial, 70 T1D, mean age 13.6 years ± 7.6 sd were calcitriol (0.25 µg on alternate days) or nicotinamide (25 mg/kg daily) followed up for 1 year. Intensive therapy implemented three daily injections regular insulin + NPH at bedtime. Results No significant differences observed between groups respect baseline/stimulated C-peptide HbA1c 1 year after diagnosis, but dose 3 6 months significantly reduced group. Conclusions At dosage used, has a modest effect only temporarily reduces dose.
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