Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset.

摘要: Background We examined patients with mild cognitive impairment (MCI) a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect beta-amyloid (Aβ) pathology on GD by using [18F]florbetapir PET. Methods Thirty-three elderly (76.7 ± 4.2 years) 22 (HC; 72.0 ± 4.5 years, average ± SD) were positron emission tomography (PET) quantify standard uptake value ratio (SUVR) as degree amyloid accumulation, MRI determine atrophy, Mini-Mental State Examination for functions, Geriatric Depression Scale severity depression, Clinical Dementia Rating activity daily living (ADL). The cut-off 1.08 SUVR was defined Aβ-positive. Results Of HC, 39.4% 27.3%, respectively, beta-amyloid-positive. onset age significantly correlated (r = 0.44, p < 0.01). Compared without Aβ (GD-Aβ), (GD + Aβ) did not differ in terms age, function, ADL, brain atrophy. GD + Aβ had older average ± SD at (73.6 ± 7.1 versus 58.7 ± 17.8, p < 0.01) shorter time between PET scan day (3.1 ± 5.2 years 18.1 ± 18.6 years, p < 0.001) than GD-Aβ. Conclusions Our results showed that rate positivity higher late-onset onset-age associated SUVR, suggesting later GD, more affected its onset. Copyright © 2014 John Wiley & Sons, Ltd.