Do grape polyphenols improve metabolic syndrome components? A systematic review

摘要: Epidemiological, in vitro and animal studies suggest that grape polyphenols, such as those present wine, have favorable effects on the metabolic syndrome. However, controversy remains whether treatment with polyphenols is effective humans. Here, we aimed to systemically review of syndrome components We systematically searched Medline, EMBASE Cochrane database for all clinical trials assessing insulin sensitivity, glycemia, blood pressure or lipid levels. screened titles reviewed abstracts potentially relevant studies. Full papers were assessed eligibility quality-rated according Jadad scale by two independent assessors. Thirty-nine met criteria. In individuals without component criteria syndrome, only low- medium-quality found primarily neutral results. related conditions, one high-quality suggested improvement sensitivity. Glycemia was improved 2 11 lower-quality 4 Seven 22 demonstrated a significant decrease pressure, but high quality. Two four pointed towards total cholesterol while other lipidemic parameters not affected. No compelling data exist can positively influence levels Limited evidence suggests may improve