Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene
作者： Liljana Petrovska , Richard J. Aspinall , Li Barber , Simon Clare , Cameron P. Simmons
DOI: 10.1111/J.1462-5822.2004.00419.X
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摘要: Summary Salmonella enterica serovar Typhimurium (S. Typhimurium) and several mutant derivatives were able to enter efficiently murine bone marrow-derived dendritic cells using mechanisms predominantly independent of the Salmonella pathogenicity island 1 type III secretion system. The levels intracellular bacteria did not increase significantly over many hours after invasion. Using fluid endocytic tracers other markers, S. Typhimurium-containing vacuoles (SCVs) physically distinguishable from early compartments. Fifty eighty per cent SCVs harbouring wild-type or aroA, invH ssaV associated with late endosome markers. In contrast, sifA was shown escape into cytosol infected cells. aroC more efficient than in delivering a eukaryotic promoter-driven green fluorescent protein reporter gene for expression detectably efficiency MHC class I presentation model antigen ovalbumin T compared similar derivative. Mice expressing develop enhanced cytotoxic cell interferon-γ production derivatives.
sci-hub.se 参考文章(69)
Marina Cella, Federica Sallusto, Antonio Lanzavecchia, Origin, maturation and antigen presenting function of dendritic cells Current Opinion in Immunology. ,vol. 9, pp. 10- 16 ,(1997) , 10.1016/S0952-7915(97)80153-7
S CHATFIELD, R STRUGNELL, G DOUGAN, Live Salmonella as vaccines and carriers of foreign antigenic determinants Vaccine. ,vol. 7, pp. 495- 498 ,(1989) , 10.1016/0264-410X(89)90271-5
M. Rescigno, S. Citterio, C. Thery, M. Rittig, D. Medaglini, G. Pozzi, S. Amigorena, P. Ricciardi-Castagnoli, Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 5229- 5234 ,(1998) , 10.1073/PNAS.95.9.5229
P. I. Fields, R. V. Swanson, C. G. Haidaris, F. Heffron, Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 5189- 5193 ,(1986) , 10.1073/PNAS.83.14.5189
Ayub Darji, Carlos A Guzmán, Birgit Gerstel, Petra Wachholz, Kenneth N Timmis, Jürgen Wehland, Trinad Chakraborty, Siegfried Weiss, Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium Cell. ,vol. 91, pp. 765- 775 ,(1997) , 10.1016/S0092-8674(00)80465-1
Mattias Svensson, Cecilia Johansson, Mary Jo Wick, Salmonella typhimurium-induced cytokine production and surface molecule expression by murine macrophages. Microbial Pathogenesis. ,vol. 31, pp. 91- 102 ,(2001) , 10.1006/MPAT.2001.0448
Kristi L. Penheiter, Nitin Mathur, Dobie Giles, Thomas Fahlen, Bradley D. Jones, Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches. Molecular Microbiology. ,vol. 24, pp. 697- 709 ,(1997) , 10.1046/J.1365-2958.1997.3741745.X
Philip D Stahl, R Alan B Ezekowitz, The mannose receptor is a pattern recognition receptor involved in host defense Current Opinion in Immunology. ,vol. 10, pp. 50- 55 ,(1998) , 10.1016/S0952-7915(98)80031-9
R. J. Mazzaccaro, M. Gedde, E. R. Jensen, H. M. van Santen, H. L. Ploegh, K. L. Rock, B. R. Bloom, Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11786- 11791 ,(1996) , 10.1073/PNAS.93.21.11786
Mary Jo Wick, The role of dendritic cells in the immune response to Salmonella. Immunology Letters. ,vol. 85, pp. 99- 102 ,(2003) , 10.1016/S0165-2478(02)00230-4