Contribution of the Extracellular Matrix and Macrophages in Angiogenesis

摘要: The formation of new capillary blood vessels, or angiogenesis, is one the most fundamental processes encountered in mammalian organisms (1–4). Angiogenesis driven by a diverse array soluble mediators, matrix molecules, and accessory cells that function to coordinate growth, differentiation, maturation capillaries strictly defined temporal spatial pattern. In recent years, role ofthe extracellular (ECM) angiogenesis enzyme systems responsible for its continuous remodeling have received considerable attention (5–9). addition providing scaffold transmission essential morphogenetic signals during development, ECM, virtue ability transmit biomechanical forces cells, has been shown exert complex local controls on functions endothelial cells. Depending composition activity proteolytic enzymes, ECM able regulate availability angiogenic mediators specify nature type interactions with integrins cellular adhesion molecules (10–16). By exerting mechanical along course developing also alter signaling patterns growth differentiation factors promote coordinated changes cytoskeleton nuclear architecture (17–19).