Neurodegenerative Disease Transmission and Transgenesis in Mice.
作者： Brittany N. Dugger , Daniel P. Perl , George A. Carlson
DOI: 10.1101/CSHPERSPECT.A023549
关键词:
摘要: Although the discovery of prion protein (PrP) resulted from its co-purification with scrapie infectivity in Syrian hamsters, work genetically defined and modified mice proved crucial for understanding fundamental processes involved not only diseases caused by PrP misfolding, aggregation, spread but also other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological conceptual approaches used to study related misfolding how these have advanced our disorders including Alzheimer's Parkinson's disease.
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