Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia

摘要: Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than behavior. However, date relative sensitivity imaging vs cognitive measures these has not been quantified. We considered effect sizes studies 9 robust SZ genes (DAOA, DISC1, DTNBP1, NRG1, RGS4, NRGN, CACNA1C, TCF4, ZNF804A) published between January 2005-November 2011. Summary data was used calculate estimates size each significant finding. The mean study categorized as small, medium, or large frequency category compared modalities across genes. Random effects meta-analysis consider impact experimental methodology on size. Imaging reported mostly medium effects, whereas investigations commonly small effects. Meta-analysis confirmed that were larger Effect negatively correlated sample but did differ a gene nor modality. These observations support notion show hence greater penetrance, when characterized using indices indexed by measures. it remains established whether this holds true individual variants, modalities, functions, how such may mediated relationship other aspects variability.