WP1066 Sensitizes Oral Squamous Cell Carcinoma Cells to Cisplatin by Targeting STAT3/miR-21 axis

摘要: Accumulating evidence reveals that activation of STAT3 and miR-21 contributes to chemoresistance in multiple tumors. We examined the expression 43 oral squamous cell carcinoma (OSCC) tumors classified them into cisplatin sensitive or resistant group. Tca8113 Tca8113/DDP cells were treated with (DDP), WP1066 (STAT3 inhibitor) combination. MTT, colony formation, wound healing, 3-D culture, transwell chamber assays used evaluate malignant phenotype OSCC cells. evaluated effect on miR-21. A xenograft tumor model was established therapeutic combination DDP. The STAT3/miR-21 significantly increased DDP-resistant samples compared its parental cell. Treatment DDP combined efficiently inhibited proliferation, migration invasion. mediated survival resistance through upregulating downregulating downstream targets, including PTEN, TIMP3 PDCD4. plus treatment could inhibit growth by inhibiting phosphorylation expression. These results indicated axis be a candidate target for chemoresistance.