Hyaluronan thiomer gel/matrix mediated healing of articular cartilage defects in New Zealand White rabbits—a pilot study

摘要: Articular cartilage defects are limited to their regenerative potential in human adults. Our current study evaluates tissue regeneration a surgically induced empty defect site with hyaluronan thiomer as provisional scaffold gel/matrix combination without cells on rabbit models restore formation. An osteochondral of 4 mm diameter and 5 mm depth was by mechanical drilling the femoral center trochlea 18 New Zealand White rabbits. Previously evaluated from an vitro matrix, gel used treat defect. As control, left untreated. During whole study, rabbits were clinically examined after 4 (n = 3) or 12 weeks, sacrificed. Joints macroscopically (Brittberg score) histology (O’Driscoll score). Synovial synovial fluid smear histopathologically evaluated. The healing varied intra-group wise at first observation period. After 12 weeks results concerning repair score inhomogeneous within each group, while macroscopic analysis more homogenous. In smear, mean infiltrated non-synovial slightly increased 4 weeks decreased both treatment groups comparison untreated control. Taken together vivo indicated that implantation matrix might enhance articular Despite benefits, intrinsic capacity is limitation for comparative test subject pre-clinical defects.