The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
作者： Rosemary E. Gale , Claire Green , Christopher Allen , Adam J. Mead , Alan K. Burnett
DOI: 10.1182/BLOOD-2007-08-109090
关键词:
摘要: An internal tandem duplication in the fms-like tyrosine kinase 3 gene (FLT3/ITD) is associated with poor prognosis acute myeloid leukemia (AML), but impact of mutant level, size, and interaction nucleophosmin 1 (NPM1) mutations remains controversial. We evaluated these characteristics a large cohort young adult AML patients. There was highly significant trend for worsening relapse risk (RR) overall survival (OS) increasing FLT3/ITD level (P
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