An early haematopoietic defect in mice lacking the transcription factor GATA-2.
作者： Fong-Ying Tsai , Gordon Keller , Frank C. Kuo , Mitchell Weiss , Jianzhou Chen
DOI: 10.1038/371221A0
关键词:
摘要: Blood cell development relies on the expansion and maintenance of haematopoietic stem progenitor cells in embryo. By gene targeting mouse embryonic cells, we demonstrate that transcription factor GATA-2 plays a critical role haematopoiesis, particularly an adult type. We propose regulates genes controlling growth responsiveness or proliferative capacity early cells.
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