Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines
作者： Subash Sad , Rita Marcotte , Tim R. Mosmann
DOI: 10.1016/1074-7613(95)90051-9
关键词:
摘要: Alloantigen-stimulated CD8+ mouse spleen cells, either spontaneously or in the presence of IL-12 IFN gamma plus anti-IL-4, differentiate into T cells secreting a Th1-like cytokine pattern (IL-2 and gamma). IL-4 induced differentiation Th2 cytokines (IL-4, IL-5, IL-6, IL-10), whereas anti-IFN suppressed development gamma. Clones IL-4- gamma-producing were relatively stable, as did not cause interconversion committed cells. Both subsets cytotoxic, failed to provide cognate help for B cell antibody production, remained CD4-, CD8 alpha+ beta+. We propose names TC1 TC2 cytotoxic Th2-like cytokines, respectively.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(53)
R K Grencis, K J Else, L Hültner, Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice. Immunology. ,vol. 75, pp. 232- 237 ,(1992)
J Leverah, D F Fiorentino, T R Mosmann, J H Schumacher, K W Moore, M W Bond, Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. Journal of Immunology. ,vol. 145, pp. 2938- 2945 ,(1990)
T R Mosmann, T A Fong, Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines. Journal of Immunology. ,vol. 144, pp. 1744- 1752 ,(1990)
S Tonkonogy, G Huston, S L Swain, A Weinberg, Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. Journal of Immunology. ,vol. 147, pp. 2991- 3000 ,(1991)
U Hochgeschwender, M M Simon, U Brugger, S Landolfo, Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors. Journal of Immunology. ,vol. 136, pp. 2755- 2762 ,(1986)
B E Torbett, G S Firestein, C T Weaver, J T Hom, K S Townsend, W D Roeder, J A Laxer, J Linton, A L Glasebrook, A new murine CD4+ T cell subset with an unrestricted cytokine profile. Journal of Immunology. ,vol. 143, pp. 518- 525 ,(1989)
A L Glasebrook, A Kelso, Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones. Journal of Immunology. ,vol. 132, pp. 2924- 2931 ,(1984)
J Hu-Li, M V Sitkovsky, H Takayama, W E Paul, G Trenn, B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes. Journal of Immunology. ,vol. 140, pp. 1101- 1106 ,(1988)
R L Coffman, J Carty, A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. Journal of Immunology. ,vol. 136, pp. 949- 954 ,(1986)
S L Swain, A D Weinberg, M English, CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. Journal of Immunology. ,vol. 144, pp. 1788- 1799 ,(1990)