Liver morphology and function in visceral leishmaniasis (Kala-azar).
作者： I A el Hag , F A Hashim , I A el Toum , M Homeida , M el Kalifa
DOI: 10.1136/JCP.47.6.547
关键词:
摘要: AIM--To study the morphology and function of liver in visceral leishmaniasis (Kala-azar). METHODS--Percutaneous biopsy specimens from 18 patients with confirmed were examined under light electron microscopy before after treatment pentovalent antimony. The tissue was also for hepatitis B surface core antigens using immunoperoxidase staining. Liver investigated nine treatment. RESULTS--Specimens showed Kupffer cells macrophages colonised by leishmania parasites 40% cases. A chronic mononuclear cell infiltrate had affected portal tracts lobules. Ballooning degeneration hepatocytes, fibrosis terminal hepatic venules, pericellular common findings. related to Ito transforming fibroblast-like cells. None infection. All biochemical evidence dysfunction improved CONCLUSION--Visceral causes morphological functional disturbance liver. Focal rather than cirrhosis occurs. exact aetiology damage is unclear but may have an immunological basis.
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