The effects of different antiemetic agents on morphine-induced emesis in ferrets

摘要: Abstract There is interest in the development of antiemetics other than dopamine receptor antagonists for treatment postoperative nausea and vomiting. A ferret model morphine-induced emesis may have wider application evaluating newer agents apomorphine dog model. This study describes conditions ferrets evaluates five that are prototypical three different mechanisms. The average numbers vomiting retching episodes induced by morphine (0.1–2.5 mg/kg s.c.) were distributed as a bell-shaped curve. Maximum number vomits occurred at 0.3 (11.8 ± 2.1 vomits; 45 12.5 retches). Antiemetics or vehicle given i.v. 5 min prior to while each was maintained under isoflurane-O 2 anesthesia. Ondansetron, 5-HT 3 antagonist, reduced 47% 70% (3 10 mg/kg). Granisetron, antagonist inactive doses 0.1, 1.0 3.0 mg.kg. Metoclopramide 48% 92% Droperidol 84% mg/kg. Naloxone 91% 43% 0.1 In most cases, prolonged latency times first accompanied reduction total episodes. significant ondansetron, metoclopramide droperidol consistent with man these compounds when component anesthetic regimen. These results suggested be useful having potential preventing treating