Live genetically engineered protozoan vaccine
作者： Stefan H. I. Kappe , Kai-Uwe C. Matuschewski , Ann-Kristin Mueller
DOI:
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摘要: The invention provides methods for inducing an immune response in a vertebrate host against protozoan parasite, comprising administering to the live parasite that is genetically engineered disrupt stage-specific gene function required by establish secondary infection host. Representative parasites belong phyla Apicomplexa and Kinetoplastida. may be mammal or bird.
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