High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients

摘要: Background Exercise is considered important in the management of patients with rheumatic diseases, but effect high intensity exercises on disease activity unknown. Objective To investigate effectiveness axial spondyloarthritis (axSpA). Method Assessor blinded multicentre randomised controlled trial. 100 (aged from their 20s to 60s) axSpA were randomly assigned an exercise group or a no-intervention control group. The performed cardiorespiratory and muscular strength at over 3 months. received standard care was instructed maintain usual physical level. Primary outcome measured Ankylosing Spondylitis (AS) Disease Activity Scale (ASDAS, higher score=worst) Bath AS Index (BASDAI, 0–10, 10=worst). Secondary outcomes inflammatory markers, function cardiovascular (CV)-health. There patient involvement design reporting this study. Results 97 (97%) completed measurements after intervention. significant treatment intervention primary (ASDAS: −0.6 [–0.8 –0.3], p Conclusion High reduced symptoms (pain, fatigue, stiffness) also inflammation axSpA. It improves patients’ CV health. This debunks concerns that might exacerbate Trial registration number NCT02356874.