Epidermal Growth Factor-Urogastrone, a Polypeptide Acquiring Hormonal Status*
DOI: 10.1016/S0083-6729(08)61068-7
关键词:
摘要: Publisher Summary This chapter discusses the characteristics of epidermal growth factor—urogastrone, a polypeptide acquiring hormonal status. The discovery, isolation, and complete sequence determination two related polypeptides, one from mouse other man, that are both highly potent stimulators cellular proliferation inhibitors gastric acid secretion is described. structure human urogastrone determined by Cohen who isolated polypeptides urine concentrates, which observed to interact with same membrane receptor demonstrated be an active mitogen in vivo vitro . physicochemical data obtained colleagues suggest as urogastrones. Human provides richest convenient source factor-urogastrone (hEGF-URO). By radioreceptor assay, it can estimated random samples male donors contain, on average, about 9.5 nmol/liter. isolation requires initial preparation either tannic acid-acetone or benzoic powder urinary proteins, followed multiple gel filtration ion exchange steps.
sci-hub.se 参考文章(135)
M D Hollenberg, D B Hope, The isolation of the native hormone-binding proteins from bovine pituitary posterior lobes. Crystallization of neurophysin-I and -II as complexes with [8-arginine]-vasopressin Biochemical Journal. ,vol. 106, pp. 557- 564 ,(1968) , 10.1042/BJ1060557
H. Gregory, S. Walsh, C.R. Hopkins, The identification of urogastrone in serum, saliva, and gastric juice. Gastroenterology. ,vol. 77, pp. 313- 318 ,(1979) , 10.1016/0016-5085(79)90284-1
C B Mann, E L Fenton, Biological effects of epithelial growth factor and its antiserum in neonatal rats Biochemical Journal. ,vol. 118, pp. 33P- 33P ,(1970) , 10.1042/BJ1180033PA
D A Farebrother, C B Mann, The histological effects of epithelial growth factor and its antiserum in the neonatal rat Biochemical Journal. ,vol. 118, pp. 33P- 34P ,(1970) , 10.1042/BJ1180033PB
STANLEY COHEN, JOHN M. TAYLOR, Epidermal growth factor: chemical and biological characterization. Recent Progress in Hormone Research. ,vol. 30, pp. 533- 550 ,(1974) , 10.1016/B978-0-12-571130-2.50017-1
Stanley Cohen, Graham Carpenter, Kenneth J. Lembach, Interaction of epidermal growth factor (EGF) with cultured fibroblasts. Advances in metabolic disorders. ,vol. 8, pp. 265- 284 ,(1975) , 10.1016/B978-0-12-027308-9.50024-X
J.Kenneth Hoober, Stanley Cohen, Epidermal growth factor: I. The stimulation of protein and ribonucleic acid synthesis in chick embryo epidermis Biochimica et Biophysica Acta. ,vol. 138, pp. 347- 356 ,(1967) , 10.1016/0005-2787(67)90495-9
G Carpenter, KJ Lembach, MM Morrison, S Cohen, Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts. Journal of Biological Chemistry. ,vol. 250, pp. 4297- 4304 ,(1975) , 10.1016/S0021-9258(19)41417-8
C. Richard Savage, Stanley Cohen, Epidermal Growth Factor and a New Derivative Journal of Biological Chemistry. ,vol. 247, pp. 7609- 7611 ,(1972) , 10.1016/S0021-9258(19)44568-7
Stanley Cohen, Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal Journal of Biological Chemistry. ,vol. 237, pp. 1555- 1562 ,(1962) , 10.1016/S0021-9258(19)83739-0