Epidermal growth factor: chemical and biological characterization.
作者： STANLEY COHEN , JOHN M. TAYLOR
DOI: 10.1016/B978-0-12-571130-2.50017-1
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摘要: Publisher Summary It has been found that partially purified extracts of submaxillary glands the male mouse cause gross anatomical changes when injected daily into newborn mice. Among specific tissue observed are precocious opening eyelids, and eruption incisors. By means a biological assay based on eyelids mouse, polypeptide responsible for this effect is isolated. The activity subsequently to be because direct stimulation proliferation keratinization epidermal tissue; therefore, termed growth factor (EGF). This chapter describes chemical physical properties EGF its activity. isolation procedure involves standard methods protein purification. Moreover, morphological biochemical effects epidermis certain epithelial tissues..
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